American Donald Young rallied from two sets down for the first time in his career as he upset 11th seed Gilles Simon 2-6, 4-6, 6-4, 6-4, 6-4 in three hours and 34 minutes. The 26-year-old Young was previously 0-17 after losing the first two sets in Grand Slam and Davis Cup play. It also marked the first time Simon lost a match from two sets up, dropping to 34-1 in his career.
Young had lost all 11 sets in his five previous matches with Simon, but turned his fortunes around against the Frenchman as he saved 21 of the 30 break points he faced. He goes on to face Aljaz Bedene, who was leading 3-6, 6-4, 3-0 when Ernests Gulbis retired from their match.
Sixth seed Tomas Berdych made light work of American Bjorn Fratangelo in the first round of the US Open on Tuesday, claiming a 6-3, 6-2, 6-4 victory in one hour and 41 minutes.
The Czech struck 37 winners and saved six of the seven break points he faced to notch his 43rd victory of the season. The 29-year-old Berdych reached the quarter-finals at Flushing Meadows last year, falling to eventual champion Marin Cilic, and was a semi-finalist in 2012 (l. to Murray).
Berdych goes on to face Jurgen Melzer, who came through qualifying before denying home hope Denis Kudla 6-3, 7-5, 6-1. Berdych leads their FedEx ATP Head2Head 4-2 and has won their past three meetings.
Top American John Isner also made a strong start, dismissing Malek Jaziri 6-2, 6-3, 6-4 in one hour and 43 minutes. Isner fired 24 aces and converted four of his 11 break points.
The 30-year-old Isner has reached two finals on the ATP World Tour this summer, winning the Atlanta title (d. Baghdatis) and finishing runner-up a week later in Washington (l. to Nishikori). His best US Open result came in 2011, when he lost a close quarter-final clash with Andy Murray.
Isner won 41 of 42 points on his first serve. "Wow, I did not know that," said Isner. "I actually felt like I could have made more first serves today, too. The percentage I think could be a little higher.
"I've played well this summer. It started in Atlanta and I played well in D.C. and Montreal. Went deep three tournaments in a row and it really did a number on me physically. I lost a super tough match in Montreal where I left it all out on the court there and didn't have much in Cincinnati. I'm rested up and I'm ready to go. I'm happy to get off the court today in a quick fashion."
Robin Haase also pulled off a great escape, rallying from two sets down to beat Dustin Brown 4-6, 4-6, 6-3, 7-5, 6-4.
Japanese 19-year-old Yoshihito Nishioka, one of 10 teenagers in the US Open main draw, claimed his first Grand Slam main draw victory as he battled past Paul-Henri Mathieu 6-4, 2-6, 6-7(7), 6-1, 6-2.
Ivo Karlovic sent down 21 aces as he defeated Federico Delbonis 6-3, 7-5, 7-5 to reach the second round. The 21st-seeded Croat goes on to challenge Jiri Vesely, a 6-4, 6-4, 6-4 victor over Paolo Lorenzi.